A Protein of Shigella Flexneri Circumvents Innate Immunity
Shigellaflexneri is able to invade and replicate within the epithelial cells, leading to severe inflammation and
epithelial damage in which the transmission process through the fecal-oral route. Epithelial cells in the intestinal tract are the
first barrier that haveimmunocompetent cells to responsible for the innate immune response. However, S. flexnerysecretes
virulence protein through the Type III Secretion System (T3SS) for disarming the innate immunity system. This review
focus on the mechanisms of S. flexneriin manipulating the innate immunity by epigenetic regulation.
Keywords- Innate immunity, Shigellaflexneri, OspF, T3SS