Paper Title
A Protein of Shigella Flexneri Circumvents Innate Immunity

Shigellaflexneri is able to invade and replicate within the epithelial cells, leading to severe inflammation and epithelial damage in which the transmission process through the fecal-oral route. Epithelial cells in the intestinal tract are the first barrier that haveimmunocompetent cells to responsible for the innate immune response. However, S. flexnerysecretes virulence protein through the Type III Secretion System (T3SS) for disarming the innate immunity system. This review focus on the mechanisms of S. flexneriin manipulating the innate immunity by epigenetic regulation. Keywords- Innate immunity, Shigellaflexneri, OspF, T3SS