Carboxymethylcellulose Coated Copper-Based Metal-Organic Framework- Nanohybrid as Drugdelivery Agent
In this work, Cu-based metal-organic framework-drug (Cu-MOF-Drug) nanohybrid protected with pH-sensitive
carboxymethylcellulose (CMC) biopolymer synthesized. Ibuprofen (IBU) as a model drug was loaded into two-dimensional
tunnels and empty face-centered cubic (FCC) cubes of Cu-MOFs porous through immersing of Cu-MOF in the drug
solution. For demonstrating the efficiency of the prepared novel hydrogel bead as an in vitro controlled drug delivery system,
the drug delivery experiments carried out in simulating the gastrointestinal tract conditions. The drug release tests showed
that the CMC encapsulated Cu-MOF-IBU nanohybrid has a better protection against stomach pH and extended the stability
of drug dosing indeed it provides controlled releases in the gastrointestinal tract conditions.
Keywords - Metal-organic framework,Carboxymethylcellulose, Hydrogel, Drug delivery, Oral delivery, Controlled release.