Modified Morphology of Mucous Cell in Stomach of Streptozotocin-Diabetic Rat
Peptic ulcer disease (PUD) is a gastrointestinal complication in the diabetes mellitus (DM) with higher incidence
than in healthy people. Normally, the mucous cells secrete mucus, which is the important protective factor to prevent and
repair gastrointestinal ulceration. Consequently, the purpose of this study was to examine the histological alterations of
mucous cells in gastric mucosa of stomach in streptozotocin (STZ)-induced diabetic rats. Five male adult Sprague-Dawley
rats in the short-termed diabetic group were intraperitoneally injected through lower part of anterior abdominal wall with the
STZ at dose of 60 mg/kg of body weight in citrate buffer. In the control group, three male rats were injected via
intraperitoneum by only the same buffer. After 4 weeks of induction, the stomach of both groups was removed for
histological technique. Under the light microscopic findings, distortions of gastric glands were found in the diabetic group.
In addition, the width of gastric gland in four areas, including pit, neck, body, and fundus in the diabetes significantly
increased, when compared with control in all regions of glandular zone of the stomach by using Mann-Whitney U test.
Moreover, some nuclei containing heterochromatin condensation and cell swelling with clear vacuoles were also shown in
both surface mucous cells and mucous neck cells of the diabetic group. This study might provide an insight into structural
changes of the mucous cells in diabetic gastric mucosa of stomach, which might relate to the development of PUD in DM.
Therefore, diabetic patients should be aware of using in ulcerogenic drugs.
Keywords - Diabetes Mellitus, Gastric Mucosa, Mucous Cell, Peptic Ulcer, Streptozotocin