Paper Title
Analgesic Anti-Inflammatory and Hepatoprotective Activities of Aerial Parts of Flacourtia Sepiaria Roxb
Abstract
The present study was carried out to investigate the in vivo acute toxicity study, analgesic anti-inflammatory and
hepatoprotective activities of various extracts of the aerial parts of Flacourtia sepiaria Roxb which belongs to the family of
Flacourtiaceae. Flacourtia sepiaria is traditionally used as an antidote for snake poisoning, rheumatoid arthritis, gout and
kidney diseases. The methanolic extract was found to be very safe up to 2000mg/kg body weight by acute toxicity model
study as per the OECD guidelines 423. The methanol extract showed significant anti-nociceptive (analgesic) antiinflammatory
and hepatoprotective activities in a dose dependent manner. The methanol extract at the dose of 400 mg/kg
exhibited significant anti-nociceptive anti- inflammatory and hepatoprotective activity. This activity can be attributed to the
phenolic and flavonoid content in the methanol extract.
Keywords— Flacourtia Sepiaria, Acute Toxicity, Analgesic, Anti-Inflammatory, Hepatoprotective.