Engineered Spheres from Unique Spider Egg Case Silk Protein
Spider eggcase silk draws increasing attention due to its unique properties. Gene recombinant technology makes
engineered silk proteins (eTuSp1) promising and versatile materials with fascinating functionalities for specific application.
The eTuSp1 spheres were formed in a lubricant-based system with rapid assembly of 10 s and the underling mechanism for
the sphere formation was studied. The effect of protein concentration on the silk spheres has been analyzed with respect to
sphere size. SEM, TEM, FTIR are used to determine the structure of silk spheres. Loaded with doxorubicin (Dox), the
potential of silk spheres is revealed for an enzyme-triggered drug delivery system.
Index Terms- drug delivery system, gene recombinant, spider eggcase silk, spheres.