Potential Antidiabetic and Anticancer Activities in the Leaves of Ipomoea Batatas (L.) Lam. Genotypes
This study investigated the antidiabetic, antimutagenicity and antioxidant activity from sweetpotato (Ipomoea batatas L.) leaves in vitro. The sweetpotato leaves extract showed stronger inhibitory activities for all the physiological functions studied. The α-glucosidase inhibition assay evaluated the antidiabetic activity, and the extract showed a considerable α-glucosidase inhibitory activity. Among the genotypes, UAPB-2 exhibited the highest a-glucoside inhibitory activity, followed by UAPB 1, and UAPB-3. The leaf extract showed the inhibitory activity ranging from 28.76% to 70.60% on a-glucosidase from 10 to 1000 mg/ml, which was increased steadily with increasing sample concentrations. Antimutagenicity in the leaves was explored using the Salmonella typhimurium TA 98. The Ipomoea batatas genotypes effectively decreased the reverse mutation induced by Trp-P-1, and the mutagenic activities were dose dependent. Furthermore, the extract also capable of reduced the reverse mutation persuaded by Trp-P-2, IQ, and DEGB extract of grilled beef. The fallouts demonstrate that antioxidant capacity (4.01 to 6.89 μmole Trolox g-1 DW) and total phenolic contents (7.89 to 17.63 μmole TA g-1 DW) broadly fluctuate among the genotypes. Our data demonstrate that all the genotypes have the physiological functions studied, and UAPB-2 exhibited the highest activities. Therefore, Sweetpotato leaves had a high concentration of naturally active biological compounds that show significant physiological functions, which might have values in the anticipation of certain human health conditions.
Index Terms- antidiabetic activity, antimutagenicity, antioxidant, sweetpotato leaves