Analgesic Anti-Inflammatory and Hepatoprotective Activities of Aerial Parts of Flacourtia Sepiaria Roxb
The present study was carried out to investigate the in vivo acute toxicity study, analgesic anti-inflammatory and hepatoprotective activities of various extracts of the aerial parts of Flacourtia sepiaria Roxb which belongs to the family of Flacourtiaceae. Flacourtia sepiaria is traditionally used as an antidote for snake poisoning, rheumatoid arthritis, gout and kidney diseases. The methanolic extract was found to be very safe up to 2000mg/kg body weight by acute toxicity model study as per the OECD guidelines 423. The methanol extract showed significant anti-nociceptive (analgesic) anti-inflammatory and hepatoprotective activities in a dose dependent manner. The methanol extract at the dose of 400 mg/kg exhibited significant anti-nociceptive anti- inflammatory and hepatoprotective activity. This activity can be attributed to the phenolic and flavonoid content in the methanol extract.
Keywords— Flacourtia Sepiaria, Acute Toxicity, Analgesic, Anti-Inflammatory, Hepatoprotective.