Paper Title :Optimalization of Medicament Dosage
Author :Lubica Krajciova, Petra Priscakova, Ladislav Czako, Vanda Repiska
Article Citation :Lubica Krajciova ,Petra Priscakova ,Ladislav Czako ,Vanda Repiska ,
(2018 ) " Optimalization of Medicament Dosage " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 17-18,
Volume-6,Issue-1,Special Issue - 1
Abstract : Warfarin is one to the most common world-wide prescribed oral anticoagulants with narrow therapeutic index.
An insufficient dose of warfarin may lead to the failure its antithrombotic effect, while overdose may increase the risk of
hemorrhage. Genetic variability in two genes CYP2C9 and VKORC1 have a significant effect on the individual's response to
the warfarin dose. The aim of our study was determine the frequency of selected single nucleotide polymorphisms in genes
CYP2C9 (CYP2C9*2 and CYP2C9*3) and VKORC1 (VKORC1*2 and VKORC1*3) in Slovak population.
Keywords - Pharmacogenetics, CYP2C9, VKORC1, drug response, Warfarin
Type : Research paper
Published : Volume-6,Issue-1,Special Issue - 1
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-11145
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Copyright: © Institute of Research and Journals
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Published on 2018-04-11 |
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