Paper Title :Phospholipid Formulation for Oral Drug Delivery

Author :Dae-Duk Kim

Article Citation :Dae-Duk Kim , (2018 ) " Phospholipid Formulation for Oral Drug Delivery " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 11-13, Volume-6,Issue-1,Special Issue - 1

Abstract : Novel proliposomes (PLs) with increased lipid content was prepared and characterized in vitro and in vivo. The solid state PLs were characterized by scanning electron microscopy (SEM), powder X-ray diffractometer (PXRD) and differential scanning calorimetry (DSC). The liposomes were reconstituted, and particle size, zeta potential , entrapment efficiency (EE) and drug loading were evaluated. Particle morphology was determined by transmission electron microscopy (TEM). In vitro dissolution and in vivo pharmacokinetic study of PLs were evaluated comparing with crude drug powder. The phospholipid content of the PLs was increased up to 20% (w/w) without stickiness. The particle size of reconstituted liposomes was 580 ± 12 nm. The zeta potential and EE of drug was -64.2 ± 0.3 mV and 78.4 ± 3.6%, respectively. Crystalline state of drug was transformed to amorphous state by incorporating in PLs. In pharmacokinetic study in rats, PLs showed shorter Tmax, higher Cmax and AUC, compared with crude drug powder. The amorphous state of the drug in the PLs resulted in increasing solubility and dissolution rate and extent of the drug incorporated, thereby increasing the oral bioavailability of drug. Index Terms - Formulation, Drug delivery, Phospholipid, Bioavailability.

Type : Research paper

Published : Volume-6,Issue-1,Special Issue - 1

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