Paper Title :Transient and Permanent Alterations of Cell Membrane Fluidity Induced by Low Intensity Medical Ultrasounds
Author :Flavio Di Giacinto, Marco De Spirito, Giuseppe Maulucci
Article Citation :Flavio Di Giacinto ,Marco De Spirito ,Giuseppe Maulucci ,
(2018 ) " Transient and Permanent Alterations of Cell Membrane Fluidity Induced by Low Intensity Medical Ultrasounds " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 16-19,
Volume-6, Issue-2, Spl. Iss-2
Abstract : Membrane fluidity, a broad term adopted to describe the physical state of biological membranes, can be altered by
local pressure variations, suchones exerted by ultrasound exposure. The alterations of lipid spatial disposition, clustering,
freedom of mobility, and/or their interactions with membrane proteins activate signal transduction pathways, regulating
several cellular functions.This work is focused on the in vitro study of the effects on membrane fluidity induced by medical
ultrasounds in murine fibroblast cells. Upon cells exposure at low intensity ofultrasounds, transient and permanent
alterations of cell membrane fluidity in different subcellular compartments are detectedat a submicrometric scale. These
alterations of membrane physical statecould provide the missing molecular mechanism linking mechanical stress and signal
transduction.
Keywords- Membrane fluidity; functional two photon microscopy; mechanotrasduction; image segmentation; ultrasounds
Type : Research paper
Published : Volume-6, Issue-2, Spl. Iss-2
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-12711
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Copyright: © Institute of Research and Journals
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Published on 2018-08-21 |
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