Paper Title :Preparation and Physicochemical Evaluation of Tocopheryl Polyethylene Glycol Succinct 1000, 5000 (Tpgs 1k, 5k) Micelles For Delivery of Paclitaxel
Author :Mahboubeh Rezazadeh, Jaber Emami, Farshid Hassanzadeh
Article Citation :Mahboubeh Rezazadeh ,Jaber Emami ,Farshid Hassanzadeh ,
(1970 ) " Preparation and Physicochemical Evaluation of Tocopheryl Polyethylene Glycol Succinct 1000, 5000 (Tpgs 1k, 5k) Micelles For Delivery of Paclitaxel " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 174-177,
Abstract : The objective of the present study was to evaluate the potential of paclitaxel (PTX) loaded mixed micelles
fabricated from to copheryl polyethylene glycol succinate 1000, 5000 (TPGS 1K, 5K) as a sustained release system. Here, we
developed a micellar system with a newly synthesized TPGS5k polymer, which showed lower CMC of 0.078 mg/ml compared
with traditional micelles prepared with TPGS1k to achieve sustained and controlled drug delivery. The blank and drug loaded
micelles were prepared in different weight ratios of TPGS1K/TPGS5K by solvent evaporation technique. Physicochemical
properties of the micelles such as critical micelle concentration, micelle size, entrapment efficiency, and release properties
were investigated in detail. The results showed that mixed micelles made of TPGS 1K and TPGS 5K (weight ratio 3:7) had
lowest CMC value, indicating that they were most stable towards dilution among micelles. Particle sizes and zeta potentials
of the micelles were in the range of 50.3–102 nm and 18.5–28.3 mV, respectively. The drug entrapment efficiencies of the
micelles were within 63.6–92.5% (w/w). The results revealed that adding TPGS 5K could increase the drug loading. The drug
loaded micelles exhibited a sustained release behavior in dissolution medium. From the micellar formulation, approximately
30% of PTX was released within 10 h at 37◦C, afterwards, the release rate slowed down and was almost complete after 5 days.
In comparisons, 50% of PTX was released rapidly from Anzatax® (PTX in Cremophor El) within 5 h and it was released
completely after 30 h.
Index Terms- Paclitaxel, α-tocopheryl polyethylene glycol succinate, Micelles
Type : Research paper
Published :
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-6063
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Copyright: © Institute of Research and Journals
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Published on 2016-11-19 |
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