Paper Title :Amitripty Line Effects on Serum Glutamate and Pain Intensity in Chronic Tension-Type Headache Patients
Author :Khairul Putra Surbakti, Hasan Sjahrir, Rosita Juwita Sembiring, Erna Mutiara
Article Citation :Khairul Putra Surbakti ,Hasan Sjahrir ,Rosita Juwita Sembiring ,Erna Mutiara ,
(2017 ) " Amitripty Line Effects on Serum Glutamate and Pain Intensity in Chronic Tension-Type Headache Patients " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 9-12,
Volume-5, Issue-2, Spl. Iss-1
Abstract : Amitriptyline has been widely used for prophylactic pharmacotherapy in patients with chronic tension-type
headache (CTTH). The aim of the present study was to determine if there were alterations in the serum levels of glutamate and
pain intensity in CTTH patients before and after 15-day treatment with amitriptyline. This randomized, controlled,
double-blind, clinical trial with pre and post test design included 73 patients with diagnosis of CTTH according to
International Classification of Headache Disorders, 2nd edition criteria. All subjects were randomized into three
interventional groups (flunarizine 5 mg/day, twenty five patients; flunarizine 10 mg/day, twenty five patients; amitriptyline
12.5 mg/day, twenty three patients). The serum level of glutamate and Numeric Rating scale (NRS) score for pain intensity
were measured before and after 15-day treatment. We found significant difference decrement of serum glutamate
concentration (p <0.001) between baseline and after 15-day in flunarizine 5 mg group and the NRS score decreased
significantly (p<0.001) was found in amitriptiline 12.5 mg group. In the present study, flunarizine showed more effective in
reducing serum glutamate concentration whereas amitriptyline more effective in reducing pain intensity and this suggest that
glutamate play a role in the patophysiology of CTTH.
Key words - Flunarizine, serum glutamate, CTTH patients, NRS score
Type : Research paper
Published : Volume-5, Issue-2, Spl. Iss-1
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-7968
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Published on 2017-07-08 |
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