Paper Title
Distribution And Comparison Of Antibiotic Resistance Pathogenicity Islands Among Upec And Dec

The Shigella resistance locus (SRL), which is carried on the pathogenicity island (PAI), mediates resistance to the multi antibiotics in entrobacteriasea including Shigella and Escherichia coli. Aims of this study were detection of multiantibiotic resistance in E. coli strains and the role of SRL PAI in this resistance. In the present study, 150 E.coli strain from stool samples and 50 E.coli strain from Urinary tract infection (UTI) samples were analyzed for PAI detection by multiplex polymerase chain reaction, frequency of antibiotic-resistance and phylogenetic groups. Most of the strains (%80) harbored at least one SRL PAI genes encoding resistance to the investigated antibiotics. The highest rates of detected SRL PAI genes were TetA (%62) following by aadA and FecA(%60). The lowest rates of detected SRL PAI genes were OXA (%27). Significant differences were observed between frequency of antibiotic resistance in stool samples and Urinary tract infection samples. The highest rates of detected phylogenetic groups was group A (%33) and the lowest rates was group B2 (%16). High frequency of PAIs and their relationships with antibiotic resistance in investigated samples highlight the important role of SRL PAIs in antibiotic resistance, especially in Urinary tract infection caused by E. coli and consistent with the hypothesis demonstrating the SRL PAI may be involved in the spread of multiple-antibiotic resistance in E. coli strains. Index Terms- E. coli, Pathogenicity Islands, antibiotic resistance, UPEC, DEC