Paper Title
Investigation On Solubility And Stability Of Curcumin In Aqueous Polysorbate Micelle

Solubility and stability are two key aspects of any successful formulation for curcumin beverage development. In the present study, the effect of polysorbate on the solubility of curcumin in aqueous solution with or without the autoclave treatment was studied. The remarkable effect of the autoclave treatment on enhancing the solubility was confirmed. Among polysorbate 20, 60 and 80, polysorbate 20 exhibited the highest solubility of approximately 6 mg/ml in 20% aqueous solution by the autoclave treatment, while the solubility was approximately 4 mg/ml in polysorbate 60 and 80, prepared under the same condition. Without the autoclave treatment, the solubility in 20% aqueous solutions of polysorbate 20, 60 and 80 was 2.7, 3.4 and 3.4 mg/ml, respectively. The stability of curcumin was obviously improved a lot by applying the micelle formation with polysorbate. However, the remarkable decomposition of curcumin at 30 and 40°C was observed over a few weeks. Dynamic light scattering study found that the curcumin and polysorbate formed the micelle (meandiameter, approximately 10nm). Through the present study, the feasibility of the development of curcumin beverage by micellar formation technique with polysorbate is confirmed though the further study for improving the stability remained untouched. Keywords- curcumin, polysorbate, autoclave, solubility