Paper Title
Effects of Estrogen on Brain Sex Differentiation

Estrogens are a class of steroid hormones that target avarious tissues almost throughout the body and wield an extensive spectrum of effects on their development, growth, differentiation and functionalities. The role of estrogens has been comprehensively studied in the governance of female reproductive abilities. Estrogens influence a variety of functions in the brain and the central nervous system and can bring about structural changes in the brain that affect adult reproductive behaviour, a process known as Brain Sex Differentiation. Xenobiotics, particularly xeno-estrogens, have debilitating effects on the overall health of both animals and human beings. They create hormonal imbalance in the body that can have repercussions on various metabolic processes. Since xenobiotics can also affect the brain to bring about sex differences, a thorough knowledge of the effects of estrogens on the brain is the need of the hour. The following review describes the complex but intriguing process of brain sex differentiation.