Paper Title :A Double-Blind Randomized Controlled Trial to Evaluate the Efficacy and Satisfaction of 0.2% Vitis Vinifera Seed Extract Cream for the Treatment of Melasma in Thai Volunteers
Author :May Pyu Thaw, Tanomkit Pawcsuntom
Article Citation :May Pyu Thaw ,Tanomkit Pawcsuntom ,
(2018 ) " A Double-Blind Randomized Controlled Trial to Evaluate the Efficacy and Satisfaction of 0.2% Vitis Vinifera Seed Extract Cream for the Treatment of Melasma in Thai Volunteers " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 16-21,
Volume-6, Issue-3, Spl. Iss-2
Abstract : Melasma is a common skin problem mostly occurs in females and can leave a significant psychological and
emotional impact on the women’s life since it mainly affects the face. Its management is difficult because of incomplete
understanding of its pathogenesis, chronicity and recurrence rates. Recent study showed that Vitis vinifera(Grape) seeds have
anti-tyrosinase activity and inhibit melanin synthesis. The objective of this study was to assess the efficacy and satisfactory
evaluation of 0.2% Vitis vinifera seed extract cream for the treatment of melasma in a double-blind, randomized, controlled
and split face clinical trial. 20 female volunteers, Fitzpatrick skin type III-VI with fulfilled criteria were enrolled. Grape seed
extract cream and standard cream base were applied comparatively by using block randomization in split face design (right
and left sides), 2 times per day for total 12 weeks. Mild soaps and sunscreens were also provided to the volunteers.
Reduction of melanin index was evaluated by Mexameter® MX18 along with photography by VISIA® at baseline, 4th week,
8th week and 12th week respectively. MASI score, satisfactory score and side effects such as pruritus, erythema, allergic
contact dermatitis, post inflammatory hyperpigmentation and hypopigmentation were also recorded. After 12 weeks of
treatment, there was a significant melanin index reduction in grape seed extract cream group from 257.41±53.58 (baseline)
to 233.53±45.44 (12th week). Also MASI score of grape seed cream side reduction from 12.58±3.16 (baseline) to 9.29±2.7
(12th week) can be seen obviously. Grape seed extract cream reduced the melasma without side effects and the patients were
very satisfied with the cream result. Therefore, Vitis viniferaseed extract cream is safe and effective in treating the melasma.
Keywords - Melasma, Melanin Reduction, Vitis vinifera, Grape Seed
Type : Research paper
Published : Volume-6, Issue-3, Spl. Iss-2
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-13755
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Published on 2018-12-13 |
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